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ARF1 ARF GTPase 1 [ Homo sapiens (human) ]

Gene ID: 375, updated on 2-Nov-2024

Summary

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Official Symbol
ARF1provided by HGNC
Official Full Name
ARF GTPase 1provided by HGNC
Primary source
HGNC:HGNC:652
See related
Ensembl:ENSG00000143761 MIM:103180; AllianceGenome:HGNC:652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PVNH8
Summary
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 152.3), thyroid (RPKM 137.5) and 25 other tissues See more
Orthologs
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Genomic context

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See ARF1 in Genome Data Viewer
Location:
1q42.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228082708..228099212)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227271693..227288198)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228270409..228286913)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Wnt family member 3A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228223992-228224955 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:228236665-228236871 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228251567-228252540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228262596-228263096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228263097-228263597 Neighboring gene long intergenic non-protein coding RNA 2809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228283911-228284880 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:228284937-228286136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228289072-228289792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228289793-228290512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228290513-228291233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228291234-228291953 Neighboring gene microRNA 3620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228295219-228295933 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228295934-228296647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2690 Neighboring gene chromosome 1 open reading frame 35 Neighboring gene mitochondrial ribosomal protein L55

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kinetic analysis of GTP hydrolysis catalysed by the Arf1-GTP-ASAP1 complex. Luo R, et al. Biochem J, 2007 Mar 15. PMID 17112341, Free PMC Article
  2. Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature. Bigay J, et al. Nature, 2003 Dec 4. PMID 14654841
  3. ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions. Schlienger S, et al. Cell Signal, 2015 Mar. PMID 25530216
  4. Conformational changes in human Arf1 on nucleotide exchange and deletion of membrane-binding elements. Seidel RD 3rd, et al. J Biol Chem, 2004 Nov 12. PMID 15308674
  5. Structural perturbations in human ADP ribosylation factor-1 accompanying the binding of phosphatidylinositides. Seidel RD 3rd, et al. Biochemistry, 2004 Dec 14. PMID 15581351

See all (284) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
    Title: Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
  2. THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the miR-320d/ARF1 axis.
    Title: THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the miR-320d/ARF1 axis.
  3. ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
    Title: ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
  4. ARF1-related disorder: phenotypic and molecular spectrum.
    Title: ARF1-related disorder: phenotypic and molecular spectrum.
  5. Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.
    Title: Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.
  6. ARF1 haploinsufficiency causes periventricular nodular heterotopia with variable clinical expressivity.
    Title: ARF1 haploinsufficiency causes periventricular nodular heterotopia with variable clinical expressivity.
  7. Cross Talk between ARF1 and RhoA Coordinates the Formation of Cytoskeletal Scaffolds during Chlamydia Infection.
    Title: Cross Talk between ARF1 and RhoA Coordinates the Formation of Cytoskeletal Scaffolds during Chlamydia Infection.
  8. Plumbagin suppresses non-small cell lung cancer progression through downregulating ARF1 and by elevating CD8(+) T cells.
    Title: Plumbagin suppresses non-small cell lung cancer progression through downregulating ARF1 and by elevating CD8(+) T cells.
  9. Downregulation of long non-coding RNA LINC00460 inhibits the proliferation, migration and invasion, and promotes apoptosis of pancreatic cancer cells via modulation of the miR-320b/ARF1 axis.
    Title: Downregulation of long non-coding RNA LINC00460 inhibits the proliferation, migration and invasion, and promotes apoptosis of pancreatic cancer cells via modulation of the miR-320b/ARF1 axis.
  10. Gbetagamma translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK.
    Title: Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK.
Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Periventricular nodular heterotopia 8
MedGen: C4748602 OMIM: 618185 GeneReviews: Not available
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Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of ADP-ribosylation factor 1 (ARF1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Functional ARF1 is required for HIV-1 Nef-dependent endogenous HLA-A2 and CD4 downregulation in HIV-infected primary T cells PubMed
nef Dominant active ARF1 (Q71L) potently stabilizes interactions among AP-1 mu1, HIV-1 Nef, and HLA-A2 and that the formation of a static complex sequesters necessary trafficking components PubMed
nef Nef binds GTPase ARF1 directly via residues E154 and E155 and recruits the GTPase to endosomal membranes PubMed
Pr55(Gag) gag GGA-mediated inhibition of virus particle release results from ARF1 sequestration, suggesting the interaction between HIV-1 Gag and ARF1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
  
enables RNA binding HDA PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendritic spine organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-term synaptic depression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic cleavage furrow ingression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor 1
Names
ADP ribosylation factor 1
NP_001019397.1
NP_001019398.1
NP_001019399.1
NP_001649.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024226.2 → NP_001019397.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_001019397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate and shorter 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK000620, BF337061, BM844480
    Consensus CDS
    CCDS1565.1
    UniProtKB/Swiss-Prot
    P10947, P32889, P84077
    UniProtKB/TrEMBL
    B4DEB9
    Related
    ENSP00000514653.1, ENST00000478424.5
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

  2. NM_001024227.1 → NP_001019398.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_001019398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AK000620, BF337061, BG421840, BQ935470
    Consensus CDS
    CCDS1565.1
    UniProtKB/Swiss-Prot
    P10947, P32889, P84077
    UniProtKB/TrEMBL
    B4DEB9
    Related
    ENSP00000514657.1, ENST00000478336.5
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

  3. NM_001024228.2 → NP_001019399.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_001019399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK000620, AL136379, BF337061, BM353046, BQ949763
    Consensus CDS
    CCDS1565.1
    UniProtKB/Swiss-Prot
    P10947, P32889, P84077
    UniProtKB/TrEMBL
    B4DEB9
    Related
    ENSP00000514658.1, ENST00000469235.5
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

  4. NM_001658.4 → NP_001649.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_001649.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate and shorter 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK000620, BF337061
    Consensus CDS
    CCDS1565.1
    UniProtKB/Swiss-Prot
    P10947, P32889, P84077
    UniProtKB/TrEMBL
    B4DEB9
    Related
    ENSP00000272102.5, ENST00000272102.10
    Conserved Domains (1) summary
    smart00177
    Location:5 → 179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    228082708..228099212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    227271693..227288198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84077.2 GenPept UniProtKB/Swiss-Prot:P84077

Gene LinkOut

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